Prognostic Molecular and Imaging Biomarkers in Primary Glioblastoma
نویسندگان
چکیده
منابع مشابه
Imaging, Diagnosis, Prognosis Prognostic Significance of Molecular Markers and Extent of Resection in Primary Glioblastoma Patients
Purpose: Despite multimodal aggressive treatment glioblastoma patients still face a rather poor prognosis. Recent data indicate that certain molecular markers, in particular MGMT promoter hypermethylation, are associated with response to alkylating chemotherapy and longer survival. The clinical significance of other glioblastoma-associated molecular aberrations and their relationship to MGMT pr...
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The exponential increase in the use of molecular biomarkers as diagnostic, prognostic, and predictive aids in the management of cancer patients highlights the increasing importance of molecular biology in oncology. The clinical utility of some molecular biomarkers like KRAS (Kirsten rat sarcoma viral oncogene homolog), BRAF (B-Raf protooncogene, serine/threonine kinase), PIK3CA (phosphatidylino...
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Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous system malignancy with a median survival of 15 months. The average incidence rate of GBM is 3.19/100,000 population, and the median age of diagnosis is 64 years. Incidence is higher in men and individuals of white race and non-Hispanic ethnicity. Many genetic and environmental factors have been studied in GB...
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Despite extensive efforts in research and therapeutics, achieving longer survival for patients with glioblastoma (GBM) remains a formidable challenge. Furthermore, because of rapid advances in the scientific understanding of GBM, communication with patients regarding the explanations and implications of genetic and molecular markers can be difficult. Understanding the important biomarkers that ...
متن کاملPrognostic significance of molecular markers and extent of resection in primary glioblastoma patients.
PURPOSE Despite multimodal aggressive treatment glioblastoma patients still face a rather poor prognosis. Recent data indicate that certain molecular markers, in particular MGMT promoter hypermethylation, are associated with response to alkylating chemotherapy and longer survival. The clinical significance of other glioblastoma-associated molecular aberrations and their relationship to MGMT pro...
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ژورنال
عنوان ژورنال: Clinical Nuclear Medicine
سال: 2017
ISSN: 0363-9762
DOI: 10.1097/rlu.0000000000001577